Ivan Ahel Lab | Publications

* denotes co-first authors who contributed equally to the published work.

ᶲ denotes co-corresponding authors.

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira Rachman, Taiasean Wu, Morgan Diolaiti, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, James S Fraser

Proceedings of the National Academy of Sciences 2023; 120 (2), e2212931120

A Simple Method to Study ADP-Ribosylation Reversal: From Function to Drug Discovery

JGM Rack, I Ahel

Poly (ADP-Ribose) Polymerase: Methods and Protocols 2022; 111-132

ADP‐ribosyltransferases, an update on function and nomenclature

Bernhard Lüscher, Ivan Ahel, Matthias Altmeyer, Alan Ashworth, Peter Bai, Paul Chang, Michael Cohen, Daniela Corda, Françoise Dantzer, Matthew D Daugherty, Ted M Dawson, Valina L Dawson, Sebastian Deindl, Anthony R Fehr, Karla LH Feijs, Dmitri V Filippov, Jean‐Philippe Gagné, Giovanna Grimaldi, Sebastian Guettler, Nicolas C Hoch, Michael O Hottiger, Patricia Korn, W Lee Kraus, Andreas Ladurner, Lari Lehtiö, Anthony KL Leung, Christopher J Lord, Aswin Mangerich, Ivan Matic, Jason Matthews, George‐Lucian Moldovan, Joel Moss, Gioacchino Natoli, Michael L Nielsen, Mario Niepel, Friedrich Nolte, John Pascal, Bryce M Paschal, Krzysztof Pawłowski, Guy G Poirier, Susan Smith, Gyula Timinszky, Zhao‐Qi Wang, José Yélamos, Xiaochun Yu, Roko Zaja, Mathias Ziegler

The FEBS journal 2022; 289 (23), 7399-7410

PARP1 proximity proteomics reveals interaction partners at stressed replication forks

Thorsten Mosler, H Irem Baymaz, Justus F Gräf, Ivan Mikicic, Georges Blattner, Edward Bartlett, Matthias Ostermaier, Rossana Piccinno, Jiwen Yang, Andrea Voigt, Marco Gatti, Stefania Pellegrino, Matthias Altmeyer, Katja Luck, Ivan Ahel, Vassilis Roukos, Petra Beli

Nucleic Acids Research 2022; 50 (20), 11600-11618

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Kang Zhu, Marcin J Suskiewicz, Andrea Hloušek-Kasun, Hervé Meudal, Andreja Mikoč, Vincent Aucagne, Dragana Ahel, Ivan Ahel

Science Advances 2022; 8 (40), eadd4253

Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2

Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira Rachman, Taiasean Wu, Morgan Diolaiti, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro Radchenko, Yurii Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, James S Fraser

bioRxiv 2022;

Mimetics of ADP-ribosylated histidine through copper (I)-catalyzed click chemistry

Hugo Minnee, Johannes GM Rack, Gijsbert A van der Marel, Herman S Overkleeft, Jeroen DC Codée, Ivan Ahel, Dmitri V Filippov

Organic Letters 2022; 24 (21), 3776-3780

Beyond protein modification: the rise of non-canonical ADP-ribosylation

M Schuller, I Ahel

Biochemical Journal 2022; 479 (4), 463-477

Fragment-Based Hit Discovery via Unsupervised Learning of Fragment-Protein Complexes

William J McCorkindale, Ivan Ahel, Haim Barr, Galen J Correy, James S Fraser, Nir London, Marion Schuller, Khriesto Shurrush, Alpha Albert Lee

bioRxiv 2022; 2022.11. 21.517375

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

Andrea Hloušek-Kasun, Petra Mikolčević, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matković, Branimir Bertoša, Ivan Ahel, Andreja Mikoč

Computational and Structural Biotechnology Journal 2022; 20, 4337-4350

Serine ADP-ribosylation in DNA-damage response regulation

L Palazzo, MJ Suskiewicz, I Ahel

Current opinion in genetics & development 2021; 71, 106-113

Noncanonical mono (ADP-ribosyl) ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity

Kong L, Feng B, Yan Y, Zhang C, Kim JH, Xu L, Rack JGM, Wang Y, Jang JC, Ahel I, Shan L, He P

Molecular Cell 2021; 81 (22), 4591-4604. e8

The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response

I Ahel, K Schützenhofer, JGM Rack

Frontiers in Cell and Developmental Biology 2021; 3119

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

Beijer D, Agnew T, Rack JGM, Prokhorova E, Deconinck T, Ceulemans B, Peric S, Milic Rasic V, De Jonghe P, Ahel I, Baets J

Life science alliance 2021; 4 (11)

TARG1 protects against toxic DNA ADP-ribosylation

C Tromans-Coia, A Sanchi, GK Moeller, G Timinszky, M Lopes, I Ahel

Nucleic acids research 2021; 49 (18), 10477-10492

The regulatory landscape of the human HPF1-and ARH3-dependent ADP-ribosylome

Hendriks IA, Buch-Larsen SC, Prokhorova E, Elsborg JD, Rebak AKLFS, Zhu K, Ahel D, Lukas C, Ahel I, Nielsen ML

Nature Communications 2021; 12 (1), 1-16

ADP-ribosylation of DNA and RNA

J Groslambert, E Prokhorova, I Ahel

DNA Repair 2021; 105, 103144

Molecular basis for DarT ADP-ribosylation of a DNA base

Schuller M, Butler RE, Ariza A, Tromans-Coia C, Jankevicius G, Claridge TDW, Kendall SL, Goh S, Stewart GR, Ahel I

Nature 2021; 596 (7873), 597-602

Mechanistic insights into the three steps of poly (ADP-ribosylation) reversal

Rack JGM, Liu Q, Zorzini V, Voorneveld J, Ariza A, Honarmand Ebrahimi K, Reber JM, Krassnig SC, Ahel D, van der Marel GA, Mangerich A, McCullagh JSO, Filippov DV, Ahel I

Nature Communications 2021; 12 (1), 1-14

Molecular Tools for the Study of ADP‐ribosylation: A Unified and Versatile Method to Synthesise Native Mono‐ADP‐ribosylated Peptides

Voorneveld J, Rack JGM, van Gijlswijk L, Meeuwenoord NJ, Liu Q, Overkleeft HS, van der Marel GA, Ahel I, Filippov DV

Chemistry–A European Journal 2021; 27 (41), 10621-10627

Serine-linked PARP1 auto-modification controls PARP inhibitor response

Prokhorova E*, Zobel F*, Smith R, Zentout S, Gibbs-Seymour I, Schützenhofer K, Peters A, Groslambert J, Zorzini V, Agnew T, Brognard J, Nielsen ML, Ahel D, Huet S, Suskiewicz MJᶲ, Ahel Iᶲ

Nature Communications 2021; 12 (1), 1-12

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

Prokhorova E, Agnew T, Wondisford AR, Tellier M, Kaminski N, Beijer D, Holder J, Groslambert J, Suskiewicz MJ, Zhu K, Reber JM, Krassnig SC, Palazzo L, Murphy S, Nielsen ML, Mangerich A, Ahel D, Baets J, O'Sullivan RJ, Ahel I

Molecular Cell 2021; 81 (12), 2640-2655. e8

Progress and outlook in studying the substrate specificities of PARPs and related enzymes

MJ Suskiewicz, L Palazzo, R Hughes, I Ahel
The FEBS Journal 2021; 288 (7), 2131-2142

Exploring protein hotspots by optimized fragment pharmacophores

Bajusz D, Wade WS, Satała G, Bojarski AJ, Ilaš J, Ebner J, Grebien F, Papp H, Jakab F, Douangamath A, Fearon D, von Delft F, Schuller M, Ahel I, Wakefield A, Vajda S, Gerencsér J, Pallai P, Keserű GM

Nature Communications 2021; 12 (1), 1-10

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT; QCRG Structural Biology Consortium, Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I

Science Advances 2021; 7 (16), eabf8711

Progress and outlook in studying the substrate specificities of PARPs and related enzymes

MJ Suskiewicz, L Palazzo, R Hughes, I Ahel
The FEBS Journal 2021; 288 (7), 2131-2142

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Hewitt G, Borel V, Segura-Bayona S, Takaki T, Ruis P, Bellelli R, Lehmann LC, Sommerova L, Vancevska A, Tomas-Loba A, Zhu K, Cooper C, Fugger K, Patel H, Goldstone R, Schneider-Luftman D, Herbert E, Stamp G, Brough R, Pettitt S, Lord CJ, West SC, Ahel I, Ahel D, Chapman JR, Deindl S, Boulton SJ

Molecular Cell 2021; 81 (4), 767-783. e11

CARM1 regulates replication fork speed and stress response by stimulating PARP1

MM Genois, JP Gagné, T Yasuhara, J Jackson, S Saxena, MF Langelier

Molecular Cell 2021; 81 (4), 784-800. e8

Behavioural characterisation of Macrod1 and Macrod2 knockout mice

K Crawford, PL Oliver, T Agnew, BHM Hunn, I Ahel
Cells 2021; 10 (2), 368

Detecting ADP-Ribosylation in RNA

D Munnur, I Ahel
RNA Modifications 2021; 231-243

ADP-ribosylation systems in bacteria and viruses

P Mikolčević, A Hloušek-Kasun, I Ahel, A Mikoč

Computational and Structural Biotechnology Journal 2021; 19, 2366-2383

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

JGM Rack, V Zorzini, Z Zhu, M Schuller, D Ahel, I Ahel

Open biology 2020; 10 (11), 200237

Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin

Bilokapic S, Suskiewicz MJ, Ahel I, Halic M

Nature. 2020 Sep;585(7826):609-613. doi: 10.1038/s41586-020-2725-7. Epub 2020 Sep 16.

Progress and outlook in studying the substrate specificities of PARPs and related enzymes

Suskiewicz MJ, Palazzo L, Hughes R, Ahel I

FEBS J. 2020 Aug 12. doi: 10.1111/febs.15518. Online ahead of print.

(ADP-ribosyl)hydrolases: structure, function, and biology

Rack JGM*, Palazzo L*, Ahel I.

Genes Dev. 2020 Mar 1;34(5-6):263-284. doi: 10.1101/gad.334631.119. Epub 2020 Feb 6.

Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

Hanzlikova H, Prokhorova E, Krejcikova K, Cihlarova Z, Kalasova I, Kubovciak J, Sachova J, Hailstone R, Brazina J, Ghosh S, Cirak S, Gleeson JG, Ahel I, Caldecott KW.

Nature Communications. 2020 Jul 7;11(1):3391. doi: 10.1038/s41467-020-17069-9.

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation

Suskiewicz MJ, Zobel F, Ogden TEH, Fontana P, Ariza A, Yang JC, Zhu K, Bracken L, Hawthorne WJ, Ahel D, Neuhaus D, Ahel I.

Nature. 2020 Mar;579(7800):598-602. doi: 10.1038/s41586-020-2013-6. Epub 2020 Feb 6.

DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair

Lawarée E, Jankevicius G, Cooper C, Ahel I, Uphoff S, M Tang CM.

Cell Rep. 2020 Feb 4;30(5):1373-1384.e4. doi: 10.1016/j.celrep.2020.01.014.

Reversible ADP-ribosylation of RNA

Munnur D, Bartlett E, Mikolčević P, Kirby IT, Rack JGM, Mikoč A, Cohen MS, Ahel I.

Nucleic Acids Res. 2019 Jun 20;47(11):5658-5669. doi: 10.1093/nar/gkz305.

ADP-ribosylation signalling and human disease

Palazzo L, Mikolčević P, Mikoč A, Ahel I.

Open Biol. 2019 Apr 26;9(4):190041. doi: 10.1098/rsob.190041.

NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair.

Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M.

Cell Rep. 2019 Feb 19;26(8):2028-2036.e6. doi: 10.1016/j.celrep.2019.01.083.

(ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.

Rack JGM, Ariza A, Drown BS, Henfrey C, Bartlett E, Shirai T, Hergenrother PJ, Ahel I.

Cell Chem Biol. 2018 Dec 20;25(12):1533-1546.e12. doi: 10.1016/j.chembiol.2018.11.001. Epub 2018 Nov 21.

Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate.

Drown BS, Shirai T, Rack JGM, Ahel I, Hergenrother PJ.

Cell Chem Biol. 2018 Dec 20;25(12):1562-1570.e19. doi: 10.1016/j.chembiol.2018.09.008. Epub 2018 Oct 11.

PARPs in genome stability and signal transduction: implications for cancer therapy.

Palazzo L, Ahel I.

Biochem Soc Trans. 2018 Dec 17;46(6):1681-1695. doi: 10.1042/BST20180418. Epub 2018 Nov 12. Review.

Interplay of Histone Marks with Serine ADP-Ribosylation.

Bartlett E, Bonfiglio JJ, Prokhorova E, Colby T, Zobel F, Ahel I ᶲ, Matic I ᶲ.

Cell Rep. 2018 Sep 25;24(13):3488-3502.e5. doi: 10.1016/j.celrep.2018.08.092.

Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer.

Voorneveld J, Rack JGM, Ahel I, Overkleeft HS, van der Marel GA, Filippov DV.

Org Lett. 2018 Jul 6;20(13):4140-4143. doi: 10.1021/acs.orglett.8b01742. Epub 2018 Jun 27.

Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.

Kwasna D, Abdul Rehman SA, Natarajan J, Matthews S, Madden R, De Cesare V, Weidlich S, Virdee S, Ahel I, Gibbs-Seymour I, Kulathu Y.

Molecular Cell. 2018 Apr 5;70(1):150-164.e6. doi: 10.1016/j.molcel.2018.02.023. Epub 2018 Mar 22.

Serine is the major residue for ADP-ribosylation upon DNA damage

Palazzo L *, Leidecker O *, Prokhorova E *, Dauben H, Matic I ᶲ, Ahel I ᶲ.

Elife. 2018 Feb 27;7:e34334 doi: 10.7554/eLife.34334.

MacroD1 Is a Promiscuous ADP-Ribosyl Hydrolase Localized to Mitochondria

Agnew T, Munnur D, Crawford K, Palazzo L, Mikoč A, Ahel I.

Front Microbiol. 2018 Jan 23;9:20. doi: 10.3389/fmicb.2018.00020. eCollection 2018.

Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis

Fehr AR *, Jankevicius G *, Ahel I, Perlman S.

Trends Microbiol. 2017 Dec 18. doi: 10.1016/j.tim.2017.11.011. [Epub ahead of print]

Specificity of reversible ADP-ribosylation and regulation of cellular processes

Crawford K, Bonfiglio JJ, Mikoč A, Matic I, Ahel I.

Crit Rev Biochem Mol Biol. 2017 Nov 3:1-19. doi: 10.1080/10409238.2017.1394265. [Epub ahead of print]

Reversible mono-ADP-ribosylation of DNA breaks

Munnur D, Ahel I.

FEBS J. 2017 Oct 20. doi: 10.1111/febs.14297. [Epub ahead of print]

Discovery of a selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerases 14

Schuller M, Riedel K, Gibbs-Seymour I, Uth K, Sieg C, Gehring AP, Ahel I, Bracher F, Kessler BM, Elkins JM, Knapp S.

ACS Chem Biol. 2017 Oct 9. doi: 10.1021/acschembio.7b00445. [Epub ahead of print]

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption

Marjanović MP, Hurtado-Bagès S, Lassi M, Valero V, Malinverni R, Delage H, Navarro M, Corujo D, Guberovic I, Douet J, Gama-Perez P, Garcia-Roves PM, Ahel I, Ladurner AG, Yanes O, Bouvet P, Suelves M, Teperino R, Pospisilik JA, Buschbeck M.

Nat Struct Mol Biol. 2017 Oct 9. doi: 10.1038/nsmb.3481. [Epub ahead of print]

Studying Catabolism of Protein ADP-Ribosylation

Palazzo L, James DI, Waddell ID, Ahel I.

Methods Mol Biol. 2017;1608:415-430. doi: 10.1007/978-1-4939-6993-7_26.

Serine ADP-ribosylation reversal by the hydrolase ARH3

Fontana P *, Bonfiglio JJ *, Palazzo L *, Bartlett E, Matic I ᶲ, Ahel I ᶲ.

Elife. 2017 Jun 26;6. pii: e28533. doi: 10.7554/eLife.28533.

ADP-Ribosylation: new facets of an ancient modification

Palazzo L *, Mikoč A * , Ahel I.

FEBS J. 2017 Apr 6. doi: 10.1111/febs.14078.

Serine ADP-Ribosylation Depends on HPF1

Bonfiglio JJ, Fontana P, Zhang Q, Colby T, Gibbs-Seymour I, Atanassov I, Bartlett E, Zaja R, Ahel I ᶲ, Matic I ᶲ.

Molecular Cell. 2017 Mar 2;65(5):932-940.e6. doi: 10.1016/j.molcel.2017.01.003.

The Toxin-Antitoxin System DarTG Catalyzes Reversible ADP-Ribosylation of DNA.

Jankevicius G *, Ariza A *, Ahel M, Ahel I.

Molecular Cell. 2016 Dec 15;64(6):1109-1116. doi: 10.1016/j.molcel.2016.11.014.

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection.

Fehr AR, Channappanavar R, Jankevicius G, Fett C, Zhao J, Athmer J, Meyerholz DK, Ahel I, Perlman S.

MBio. 2016 Dec 13;7(6). pii: e01721-16. doi: 10.1128/mBio.01721-16.

Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor.

Lalić J *, Posavec Marjanović M *, Palazzo L *, Perina D, Sabljić I, Žaja R, Colby T, Pleše B, Halasz M, Jankevicius G, Bucca G, Ahel M, Matić I, Ćetković H, Luić M, Mikoč A, Ahel I.

J Biol Chem. 2016 Oct 28;291(44):23175-23187.

Serine is a new target residue for endogenous ADP-ribosylation on histones.

Leidecker O, Bonfiglio JJ, Colby T, Zhang Q, Atanassov I, Zaja R, Palazzo L, Stockum A, Ahel I, Matic I

Nature Chemical Biology. 2016 Dec; 12(12):998-1000:. doi: 10.1038/nchembio.2180.

PARP, transcription and chromatin modeling.

Posavec Marjanović M, Crawford K, Ahel I.

Semin Cell Dev Biol. 2016 Sep 24. pii: S1084-9521(16)30308-1.

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair.

Gunn AR *, Banos-Pinero B *, Paschke P, Sanchez-Pulido L, Ariza A, Day J, Emrich M, Leys D, Ponting CP, Ahel I ᶲ, Lakin ND ᶲ.

J Cell Sci. 2016 Oct 15;129(20):3845-3858.

MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the DNA Damage Response.

Staples CJ, Barone G, Myers KN, Ganesh A, Gibbs-Seymour I, Patil AA, Beveridge RD, Daye C, Beniston R, Maslen S, Ahel I, Skehel JM, Collis SJ.

Cell Rep. 2016 Sep 6;16(10):2565-75.

Viral Macro Domains Reverse Protein ADP-Ribosylation.

Li C, Debing Y, Jankevicius G, Neyts J, Ahel I, Coutard B, Canard B.

J Virol. 2016 Sep 12;90(19):8478-86.

ENPP1 processes protein ADP-ribosylation in vitro.

Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I.

FEBS J. 2016 Sep;283(18):3371-88.

HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity.

Gibbs-Seymour I, Fontana P, Rack JG, Ahel I.

Molecular Cell. 2016 May 5;62(3):432-42.

Macrodomains: Structure, Function, Evolution, and Catalytic Activities.

Rack JG, Perina D, Ahel I.

Annu Rev Biochem. 2016 Jun 2;85:431-54.

Identifying Family-Member-Specific Targets of Mono-ARTDs by Using a Chemical Genetics Approach.

Carter-O'Connell I, Jin H, Morgan RK, Zaja R, David LL, Ahel I, Cohen MS.

Cell Rep. 2016 Jan 26;14(3):621-31.

Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens.

Rack JG *, Morra R *, Barkauskaite E *, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I.

Molecular Cell. 2015 Jul 16;59(2):309-20.

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.

Barkauskaite E, Jankevicius G, Ahel I.

Molecular Cell. 2015 Jun 18;58(6):935-46.

Processing of protein ADP-ribosylation by Nudix hydrolases.

Palazzo L, Thomas B, Jemth AS, Colby T, Leidecker O, Feijs KL, Zaja R, Loseva O, Puigvert JC, Matic I, Helleday T, Ahel I.

Biochem J. 2015 Jun 1;468(2):293-301.

Synthesis of dimeric ADP-ribose and its structure with human poly(ADP-ribose) glycohydrolase.

Lambrecht MJ, Brichacek M, Barkauskaite E, Ariza A, Ahel I, Hergenrother PJ.

J Am Chem Soc. 2015 Mar 18;137(10):3558-64.

Distribution of protein poly(ADP-ribosyl)ation systems across all domains of life.

Perina D, Mikoč A, Ahel J, Ćetković H, Žaja R, Ahel I.

DNA Repair (Amst). 2014 Nov;23:4-16.

Family-wide analysis of poly(ADP-ribose) polymerase activity.

Vyas S, Matic I, Uchima L, Rood J, Zaja R, Hay RT, Ahel I, Chang P.

Nature Communications. 2014 Jul 21;5:4426.

Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response.

Tallis M, Morra R, Barkauskaite E, Ahel I.

Chromosoma. 2014 Mar;123(1-2):79-90.

Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities.

Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I ᶲ, Leys D ᶲ.

Nature Communications. 2013;4:2164.

The recognition and removal of cellular poly(ADP-ribose) signals.

Barkauskaite E, Jankevicius G, Ladurner AG, Ahel I, Timinszky G.

FEBS J. 2013 Aug;280(15):3491-507.

Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.

Sharifi R *, Morra R *, Appel CD *, Tallis M, Chioza B, Jankevicius G, Simpson MA, Matic I, Ozkan E, Golia B, Schellenberg MJ, Weston R, Williams JG, Rossi MN, Galehdari H, Krahn J, Wan A, Trembath RC, Crosby AH, Ahel D, Hay R, Ladurner AG, Timinszky G, Williams RS, Ahel I.

EMBO J. 2013 May 2;32(9):1225-37.